The RM Nimbus PC-186 mouse predates the serial/USB era and actually transmits raw data regarding its position, known as quadrature. The port on the back of the PC-186 is not a serial port but a dedicated Mouse/Joystick port.
At the time of launch in 1985 the Mouse was an option extra, priced at £87!
Here we show the teardown of a Logitech 2F-RM
Here are some additional examples of the Nimbus Mouse